Mast cells in biopsies of fibrosing alveolitis
Dusková, J.; Dobiás, K.
Ceskoslovenska Patologie 18(1): 36-44
1982
ISSN/ISBN: 1210-7875 PMID: 7060164 Document Number: 194174
The mechanism of fibroproduction of the lung tissue in fibrosing alveolitis is connected with the presence of mixed cell exudate, persevering interalveolar and peribronchial edema and proliferation of glycoproteins. As the multiplication of heparinocytes in the conditions of fibrosing alveolitis as against the material compared in conclusive, we may infer that the release of their mediators leads to dilatation of interalveolar capillaries, to an increase in their permeability and thus to the origin of interstitial edema. The release of biogenic amines from the granules of heparinocytes is a possible agent even in the chemotactic influence on neutrophilic and eosinophilic granulocytes and thrombocytes. The fact that heparinocytes proliferate even in the latter phases of inflammation indicates that they create conditions for the perseverance of inflammatory exudation and interstitial edema. And this may be regarded as a direct cause of fibroproduction.