Neocytes and neocyte-gerocyte exchange
Propper, R.D.
Progress in Clinical and Biological Research 88: 227-233
1982
ISSN/ISBN: 0361-7742 PMID: 7100213 Document Number: 192560
Patients requiring chronic transfusions deposit large quantities of iron throughout their reticuloendothelial and parenchymal systems. Diabetes mellitus, hepatic fibrosis, and cardiomyopathy are the ultimate pathologic manifestations. One mechanism for decreasing the rate of iron loading would be to transfuse only the youngest cohort of cells from a donor (neocytes). At the same time the patient's oldest red cells are being removed (neocyte-gerocyte exchange). In this manuscript we describe techniques presently available for such a procedure.