Action of Bordetella pertussis vaccine on mouse hematopoietic stem cells

Khorobrykh, V.V.; Barteneva, N.S.; Sanin, A.V.; Snegireva, A.E.

Biulleten' Eksperimental'noi Biologii i Meditsiny 93(6): 107-110

1982


ISSN/ISBN: 0365-9615
PMID: 7115919
Document Number: 191938
Intravenous inoculation of killed Bordetella pertussis vaccine into BALB/c, CBA, C57Bl/6 mice or (CBA x C57Bl/6) F2 hybrids 1 day or 3 days before sublethal irradiation (5.5 Gy) was shown to sharply increase the endogenous colony formation in the spleen 9 days after irradiation. Moreover, the CFUs content of the spleen and bone marrow was also enhanced 1 and 3 days after vaccination of the mice with 10(10) cells B. pertussis as revealed by the exocolonization technique (Till and McCulloch). Thus, a single injection of B. pertussis vaccine hastened the hematopoietic recovery after irradiation.

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