Relation between dose and blood system damage during protracted exposure to radiation
Gorlov, V.G.; Neiman, O.V.
Kosmicheskaia Biologiia i Aviakosmicheskaia Meditsina 16(1): 86-89
1982
ISSN/ISBN: 0321-5040 PMID: 7062705 Document Number: 191778
Experiments were carried out on rats irradiated for 22-23 h daily with doses of 300, 100 and 50 R for revealing effects of radiation from high energy solar explosions in space flights. The decrease of total bone marrow cells during the phase of primary destruction was subordinated to an exponential law. The effect of the dose rate prevailed at later phases. Bone marrow reticular cells and peripheral blood had a high radiosensitivity. Analysis of thrombocytopoiesis revealed a decrease of platelet quantity [PQ] during the 1st day of irradiation, followed by an increase of their number or retention of their quantity. The PQ was one of the most sensitive tests in evaluation of prolonged radiation effects [PRE]. Dose effect curves demonstrated that almost all hemopoietic cell populations differed in radiation sensitivity. A period of equilibrium between damaging processes and restoration occurred as a result of resistant cell selection in the hemopoietic system. The rate of hemopoietic damage was revealed by counting the quantity of lymphocytes, peripheral blood platelets, content of lymphoid elements, erythronormoblasts and total bone marrow cells. Using the obtained data, the bone marrow hemopoietic state could be predicted at a given moment in time during PRE.