Selective inhibition of microcirculation in tumor tissue by manipulated blood pressure reduction
von Ardenne, M.; Reitnauer, P.G.
Archiv für Geschwulstforschung 52(5): 363-370
1982
ISSN/ISBN: 0003-911X PMID: 7149910 Document Number: 191666
It was shown on the DS-carcinosarcoma of rat that NAD-induced blood pressure reduction to 50% of the initial value is followed by a selective compression ischemia in the tumor tissue. In this period that can be prolonged to at least 10 min by infusion of NAD the microcirculation in the tumor tissue is almost completely inhibited. Determinations of the blood volume confirm the results obtained bei O. D. measurements. The significance of this finding and its eventual utilization (cancer therapy) are discussed.