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Comparison of effects of tetrandrine, verapamil and propranolol on myocardial blood flow

Xia, G.J.; Jia, J.F.; Wu, Z.C.; Fang, D.C.; Jiang, M.X.

Zhongguo Yao Li Xue Bao 3(4): 230-233

1982

ISSN/ISBN: 0253-9756
PMID: 6219537
Document Number: 191194
By 86RbCl-extraction method the effects of tetrandrine (Tet), verapamil (Ver) and propranolol (Pro) on myocardial blood flow of mice were studied. Both i.p. Tet 100 mg/kg and Ver 5 mg/kg increased the blood flow, whereas Pro 30 mg/kg did not. Pro counteracted significantly the increase of myocardial blood flow by isoprenaline while Tet and Ver failed. Tet and Ver markedly antagonized the increase of myocardial blood flow by CaCl2, but Pro did not. Tet, differing from the .beta.-receptor blocking agent Pro, may be a Ca antagonist similar to Ver.

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