Isolation of rat major histocompatibility genes expressed in pancreatic beta-cells
Kastern, W.H.; Lernmark, A.; Lyngsie, L.
Acta Biologica et Medica Germanica 41(12): 1135-1138
1982
ISSN/ISBN: 0001-5318 PMID: 6765156 Document Number: 190657
The probable role of cell surface antigens in the development of juvenile diabetes necessitates a detailed study of the proteins expressed on the surface of pancreatic beta-cells. A gene library composed of genes expressed in beta-cells was constructed to provide a source of low abundance genes from those cells. Initial studies with this library have led to the isolation of three genes which share nucleotide and amino acid sequence homology with mouse and human class I major histocompatibility antigens.
Document emailed within 1 workday
Related Documents
Silverman, T.; Rein, A.; Orrison, B.; Langloss, J.; Bratthauer, G.; Miyazaki, J.; Ozato, K. 1988: Establishment of cell lines from somite stage mouse embryos and expression of major histocompatibility class I genes in these cells Journal of Immunology 140(12): 4378-4387Hiller, W.F.; Steiniger, B.; Klempnauer, J. 1990: Nonendocrine pancreatic cells determine the immunogenicity of major histocompatibility class II-incompatible islets of Langerhans Transplantation Proceedings 22(6): 2526-2527
Masuda, K.; Li, Q.; Yamada, Y.; Seino, Y. 1994: The alpha 1 subunit of voltage-dependent calcium channel expressed in pancreatic beta cells Nihon Rinsho. Japanese Journal of Clinical Medicine 52(10): 2593-2598
Gambari, R. 1983: Hexamethylenebisacetamide-mediated induction of murine erythroleukemia cells: relationship between expression of beta major and beta minor globin genes, globin mRNA synthesis and commitment to erythroid differentiation Biochemistry International 7(4): 471-480
Burke, P.A.; Ozato, K. 1989: Regulation of major histocompatibility complex class i genes Year in Immunology 4: 23-40
Van der Feltz, M.J.; van der Korput, J.A.; Giphart, M.J.; Westbroek, D.L. 1981: The major histocompatibility complex of the dog. Isolation and partial characterization of the SD antigens Transplantation 32(3): 253-255
Coady, M.A.; Mandapati, D.; Arunachalam, B.; Jensen, K.; Maher, S.E.; Bothwell, A.L.; Hammond, G.L. 1999: Dominant negative suppression of major histocompatibility complex genes occurs in trophoblasts Transplantation 67(11): 1461-1467
Matsuyama, T.; Winchester, R.; Lee, S.; Shookster, L.; Nunez-Roldan, A. 1988: Identification of the DRw10 DR beta 1-chain allele as encoding a polymorphic class Ii major histocompatibility complex epitope otherwise restricted to DR beta 2 molecules of the DRw53 type Journal of Immunology 140(2): 537-543
Kloepfer, H.W. 1982: Parameters used to describe less common single major genes expressed in dermatoglyphic features Progress in Clinical and Biological Research 84: 105-109
Pankratova, E.V. 1988: Structure and function of antigen-recognizing proteins coded by major histocompatibility complex genes Molekuliarnaia Biologiia 22(5): 1157-1163
Mallard, B.A.; Wilkie, B.N.; Kennedy, B.W. 1989: Influence of major histocompatibility genes on serum hemolytic complement activity in miniature swine American Journal of Veterinary Research 50(3): 359-363
McCluskey, J.; Bluestone, J.A.; Coligan, J.E.; Maloy, W.L.; Margulies, D.H. 1986: Serologic and T cell recognition of truncated transplantation antigens encoded by in vitro deleted class i major histocompatibility genes Journal of Immunology 136(4): 1472-1481
Miyashita, T.; Tajima, H.; Shoji, M.; Nakanuma, S.; Sakai, S.; Makino, I.; Hayashi, H.; Nakagawara, H.; Takamura, H.; Kitagawa, H.; Ohta, T. 2013: Gemcitabine augments major histocompatibility complex class I-related chain a expression in pancreatic cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 40(12): 1600-1602
Acton, R.T.; Bell, D.S.; Collins, J.; Giger, J.N.; Go, R.C.; Harrison, R.; McDonald, R.; Rivers, C.; Roseman, J.M.; Taylor, H.A.; Vanichanan, C. 1997: Genes within and flanking the major histocompatibility region are risk factors for diabetes, insulin resistance, hypertension, and microalbuminuria in African-American women Transplantation proceedings 29(8): 3710-3712
Tovey, M.G.; Content, J.; Gresser, I.; Gugenheim, J.; Blanchard, B.; Guymarho, J.; Poupart, P.; Gigou, M.; Shaw, A.; Fiers, W. 1988: Genes for IFN-beta-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals Journal of Immunology 141(9): 3106-3110
Ali, A.; Garrovillo, M.; Jin, M.X.; Hardy, M.A.; Oluwole, S.F. 2000: Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cells Transplantation 69(2): 221-226
Anfalova, T.V.; Galaktionov, V.G.; Golenishchev, V.I.; Lutsan, N.I. 1986: Control by genes of the major histocompatibility complex of macrophage-thymocyte interaction during induction of T-effectors of graft versus host reaction. II. Analysis at the level of humoral factor activity Genetika 22(3): 467-472
Xiang, J.; Moyana, T. 1998: Cytotoxic CD4+ T cells associated with the expression of major histocompatibility complex class II antigen of mouse myeloma cells secreting interferon-gamma are cytolytic in vitro and tumoricidal in vivo Cancer Gene Therapy 5(5): 313-320
Tamura, K.; Shimizu, K.; Yamada, M.; Okamoto, Y.; Matsui, Y.; Park, K.C.; Mabuchi, E.; Moriuchi, S.; Mogami, H. 1989: Expression of major histocompatibility complex on human medulloblastoma cells with neuronal differentiation Cancer Research 49(19): 5380-5384
Nakayama, T.; Kubo, M.; Gomi, H.; Asano, Y.; Tada, T. 1987: Major histocompatibility complex-restricted augmenting T cells induced by in vitro cultivation of antigen-primed T cells. a new parallelism between suppressor and augmenting circuits Journal of Immunology 139(12): 3935-3941