Experimental model with the additional source of endogenous serotonin
Popova, N.K.; Kudriavtseva, N.N.; Guvakova, T.V.; Enishevskaia, N.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 93(3): 99-101
1982
ISSN/ISBN: 0365-9615 PMID: 7093493 Document Number: 190235
The only experimental approach to the increase in the body serotonin level is a pharmacological one that has a number of shortcomings. The authors suggest an experimental model with additional source of endogenous serotonin (ASS-model) which occurs after embryonal gastrointestinal tract transplantation beneath the skin of adult syngeneic mice. The developing transplants showed significant amounts of serotonin and serotonin-producing enterochromaffin cells. The ASS-model provides long-term and selective increase in the blood serotonin content (by 40% on the average) with no changes being detected in the brain. This model may be used for studies on the role of serotonin in peripheral regulation of the physiological systems.