Dimethylhydrazine-induced colonic neoplasia: dissociation from endogenous gastrin levels
Oscarson, J.E.; Veen, H.F.; Ross, J.S.; Malt, R.A.
Surgery 91(5): 525-530
1982
ISSN/ISBN: 0039-6060 PMID: 7071741 Document Number: 189727
The potential tropic effect of gastrin in promoting colonic carcinogenesis was tested in rats (n = 133) with 6- to 16-fold variations in endogenous gastrin resulting from antrectomy or fundectomy, followed by 12 injections of 1,2-dimethylhydrazine (10 mg/kg). The incidence and grade of differentiation of resulting tumors, as well as the thickness, content of nucleic acids, and specific activity of DNA in colonic mucosa, were similar in both high-gastrin and low-gastrin animals and were unchanged from data in unoperated control animals receiving only the carcinogen. Long-term changes in endogenous gastrin concentration are not followed by colonic mucosal tropic effects, and gastrin does not act as a cofactor in dimethylhydrazine-induced carcinogenesis at this dosage.