Vasopressin: action on WRK-1 rat mammary tumor cells
Monaco, M.E.; Kohn, P.H.; Kidwell, W.R.; Strobl, J.S.; Lippman, M.E.
Journal of the National Cancer Institute 68(2): 267-270
1982
ISSN/ISBN: 0027-8874 PMID: 6801367 Document Number: 188626
WRK-1, a cell line in long-term culture derived from a 7, 12-dimethylbenzanthracene-induced rat mammary tumor, responds to physiologic concentrations of vasopressin with increased precursor incorporation into phospholipids and with increased protein accumulation. Because vasopressin has been reported to be a potent mitogen for Hela cells and 3T3 cells, a study was conducted to determine whether it could act as a mitogen for WRK-1 cells. Under no conditions was a clear-cut mitogen response to vasopressin demonstrated.