The experimental and clinical studies on cefsulodin in the pediatric field
Akita, H.; Iwata, S.; Iwasaki, Y.; Kanemitsu, T.; Hattori, H.; Jozaki, K.; Hotta, M.; Yamashita, N.; Nanri, S.; Sunagawa, K.; Iwata, T.; Osano, M.; Ichihashi, Y.
Japanese Journal of Antibiotics 35(11): 2652-2656
1982
ISSN/ISBN: 0368-2781 PMID: 7169665 Document Number: 188226
A new cephalosporin cefsulodin (CFS) was studied basically and clinically and the following results were obtained. 1. The serum levels of 25 mg/kg of CFS administered intravenously were 39.5 mcg/ml after 30 minutes, 22.6 mcg/ml after 1 hour, 11.6 mcg/ml after 2 hours, 6.0 mcg/ml after 4 hours and 2.1 mcg/ml after 6 hours. The half life from serum was 84 minutes. 2. Clinical response on 4 cases of Pseudomonas aeruginosa infections were all good. 3. The slight elevations of GOT, GPT were observed by the drug administrations in 1 case. From the above results, CFS was effective drug to P. aeruginosa infections by intravenous administration of 25 mg/kg of CFS.