Pharmacokinetics of albendazole in children with hydatid disease
Okelo, G.B.; Hagos, B.; Ng'ang'a, J.N.; Ogeto, J.O.
East African Medical Journal 70(10): 643-645
1993
ISSN/ISBN: 0012-835X PMID: 8187662 Document Number: 188
The pharmacokinetics of albendazole were investigated in five children who were hospitalized at the Kenyatta National Hospital for the treatment of hydatid disease. Unchanged albendazole was below detectable level in plasma. The major metabolite present was albendazole sulphoxide. In one of the patients, the concentration of albendazole sulphone in plasma was significantly high, whereas in the other four children, only trace amounts were detected. Maximum concentrations of albendazole sulphoxide in these five children were variable and generally higher than those reported in adults by other workers. Other pharmacokinetic parameters were comparable to those found in other studies.
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