The effect of etretinate on fibronectin in psoriatic skin
Lauharanta, J.; Salo, O.; Kanerva, L.; Lassus, A.
Acta Dermato-Venereologica 62(4): 358-361
1982
ISSN/ISBN: 0001-5555 PMID: 6183879 Document Number: 187551
The distribution of fibronectin in psoriatic skin was studied in 6 patients during treatment with oral etretinate using indirect immunofluorescence technique. In untreated lesions fibronectin was clearly visualized in the dermo-epidermal junction (DEJ) and in the walls of papillary capillaries, and showed a reticular or fibrillar pattern in the dermis. In the horny layer there was some fluorescence which was regarded largely as unspecific. In all patients a transient accentuation of fibronectin accumulation in the DEJ was seen after 3-7 days of treatment. Except for some decrease in the amount and intensity of capillary fluorescence, no other notable changes occurred in the fibronectin distribution during 4 wk of treatment.