Phospholipid composition of normal thrombocytes and in diabetes mellitus
Saatov, T.S.; Abidov, A.A.; Isamitdinova, I.M.
Problemy Endokrinologii 28(5): 3-6
1982
ISSN/ISBN: 0375-9660 PMID: 7145882 Document Number: 187547
Adhesive and aggregating properties of the blood platelets are dependent to a higher degree on phospholipid content of their cellular membranes. A tendency of the blood platelets to hyperaggregation was seen in patients with diabetes mellitus. The aim of these studies is to investigate lipid composition of the blood platelets in healthy subjects and in patients with diabetes mellitus during the treatment. Sixty five diabetic patients and 18 healthy humans were examined. A significant decrease in sphingomyelin content down to 10.4% (normal 15.2%) and an increase in phosphatidylserine concentration up to 11.7% (normal 6.8%) were observed in diabetic patients in the process of determination of phospholipid content in the blood plate lets. The changes were revealed in phospholipid content, when calculation was carried out in micrograms/100 mg of protein. During the decompensation stage a decreased concentration of total phospholipids and their choline-containing fractions is observed in the presence of rising phosphatidyl and cholesterol contents and the cholesterol-phospholipid ratio. In diabetes compensation stage the lipid composition of the blood platelets is absolutely within normal.