Renal amyloidosis in related Abyssinian cats
Chew, D.J.; DiBartola, S.P.; Boyce, J.T.; Gasper, P.W.
Journal of the American Veterinary Medical Association 181(2): 139-142
1982
ISSN/ISBN: 0003-1488 PMID: 7118693 Document Number: 187316
Renal amyloidosis was diagnosed in eight related Abyssinian cats. The kidneys were characterized pathologically by medullary interstitial and glomerular amyloid deposition, interstitial fibrosis, and papillary necrosis. Amyloid deposits were birefringent under polarized light after Congo red staining, were thioflavine-T positive, and lost Congo red staining after permanganate oxidation. Four of the cats were evaluated clinically. Two of these cats were terminally uraemic, with nonregenerative anaemia, azotaemia, hyperphosphataemia, metabolic acidosis, mild hyperglycaemia, isosthenuria, proteinuria, cylindruria, and mild haematuria. The remaining two cats were only moderately azotaemic. Three of the cats had severe gingivitis and all four cats had hyperproteinaemia due to hyperglobulinaemia.