Oral treatment of continuous ventricular extrasystole with detajmiumbitartrate (Tachmalcor) --clinical studies on effectiveness and dose-time-effect relations including intraindividual therapy comparisons with ajmaline (Tachmalin)
Wruck, C.; Hofmann, H.; Sziegoleit, W.; Förster, W.
Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 37(16): 519-525
1982
ISSN/ISBN: 0044-2542 PMID: 6183840 Document Number: 186025
On 31 inpatients with ventricular permanent extrasystoles (12 females, 19 males) at the age of 17--17 years altogether 45 oral experiments of rhythmisation were performed, on them 29 times with the ajmalium derivate detajmium bitartrate (Tachmalcor) and 16 times with ajmalin (Tachmalin). In 14 cases the comparison of the effect of the two substances was performed in the intraindividual test. In ventricular extrasystoles the ajmalin derivation compared with the initial substance was significantly more effective antiarrhythmically already when the half dose was used. However, it led at the same time to a greater retardation of the intracardiac stimulus conduction. Heart rate and blood pressure were influenced only at the beginning of the treatment and only unessentially. The subjective tolerability was very good. In 9 cases with oral ambulatory long-term treatment the daily maintenance doses of 75--100 mg detajmium bitartrate proved to be fully effective in therapeutic respect. Practical therapeutic conclusions are derived from the results obtained.