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Effect of vinblastine, vincristine, and vindesine on neutrophil phagocytosis and iodination

Chohan, V.; Lowenthal, R.M.

Cancer Treatment Reports 66(3): 505-508

1982

ISSN/ISBN: 0361-5960
PMID: 7037181
Document Number: 185966
The ability of neutrophils to phagocytose Saccharomyces cerevisiae and iodinate Staphylococcus aureus and Candida albicans was evaluated when the neutrophils were incubated with therapeutic and above-therapeutic concentrations of vinblastine, vincristine or vindesine. The phagocytic capacity, but not the phagocytic rate, was decreased in the presence of vincristine but not the other drugs. Above-therapeutic concentrations of vinblastine and vincristine reduced the iodination of C. albicans when compared with the control. Therapeutic doses of these drugs apparently were not detrimental to important neutrophil functions.

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