Comparative study of pirprofen and ketoprofen in the treatment of osteoarthritis of the hip and of the knee
Peyron, J.; Doury, P.
La Nouvelle Presse Medicale 11(33): 2497-2499
1982
ISSN/ISBN: 0301-1518 PMID: 6752875 Document Number: 185363
One hundred and eighty three patients suffering from osteoarthritis of either the hip or the knee were treated during two successive two-week periods by 800 mg/day of pirprofen and 300 mg/day of ketoprofen (two dosages). The order of the treatments was determined randomly. This cross-over was conducted in double blind in 9 rheumatological centers. The efficacy and tolerance of the treatments were evaluated after the first two weeks and at the end of the trial. Pirprofen and ketoprofen showed a definite and comparable efficacy in 70% of patients. The tolerance was acceptable in 86% of patients in the pirprofen groupe and 87% for ketoprofen. Side effects, primarily digestive, were noted with equal frequency (32%). The findings of our study are that a daily dose of 800 mg of pirprofen in the treatment of osteoarthritis of the knee and hip provides an efficacy identical to that of 300 mg/day of ketoprofen with an equally good tolerance.