Paradoxical effect of radiation on tumor incidence in the rat: implications for radiation therapy
Hellman, S.; Moloney, W.C.; Meissner, W.A.
Cancer Research 42(2): 433-436
1982
ISSN/ISBN: 0008-5472 PMID: 7055798 Document Number: 185092
The high incidence of leukemia in the Fischer rat is reduced by radiation to an incidence below that seen spontaneously. Fractionating the radiation decreased this effect. In contrast, mammary tumors increased with dose until reaching a plateau at the highest doses. Fractionation had little effect. These results are consistent with a hypothesis suggesting that tumor incidence due to radiation is the result of competing processes of tumor induction and cell killing.
Document emailed within 1 workday
Related Documents
Li, J.-m.; Yu, J.-m.; Liu, S.-w.; Chen, Q.; Mu, X.-k.; Jiang, Q.-a.; Zhao, M.-h.; Zhang, J.-g. 2009: Dose distributions of proton beam therapy for hepatocellular carcinoma: a comparative study of treatment planning with 3D-conformal radiation therapy or intensity-modulated radiation therapy Zhonghua Yi Xue Za Zhi 89(45): 3201-3206Gao, Q-Neng. 2019: Stereotactic body radiation therapy versus conventional intensity-modulated radiation therapy for the treatment of prostate cancer Zhonghua Nan Ke Xue 25(5): 424-429
2015: (S018) intensity-modulated radiation therapy or conformal radiation therapy and cardiopulmonary mortality risk in the elderly with esophageal cancer Oncology 29(4 Suppl. 1)
Lertbutsayanukul, C.; Shotelersuk, K.; Khorprasert, C.; Sanghangthum, T.; Oonsiri, S.; Ayuthaya, I.Israngkul.Na.; Jumpangern, C.; Suriyapee, S.; Rojpornpradit, P. 2008: A two-year experience of implementing 3 dimensional radiation therapy and intensity-modulated radiation therapy for 925 patients in King Chulalongkorn Memorial Hospital Journal of the Medical Association of Thailand 91(2): 215-224
2016: (S034) Frequency of Whole-Breast Radiation Therapy Following Intraoperative Radiation Therapy Due to Criteria Identified by Lumpectomy Oncology 30 Suppl
Libický, A.; Urban, J.; Chottová, O.; Fidlerová, J. 1980: The effect of ionizing radiation on enzymes. I. the effect of gamma radiation on proteolytic activity of pancreatin of various degrees of purity Ceskoslovenska Farmacie 29(1-2): 14-18
Gillette, S.M.; Gillette, E.L.; Powers, B.E.; Withrow, S.J. 1990: Radiation-induced osteosarcoma in dogs after external beam or intraoperative radiation therapy Cancer Research 50(1): 54-57
Baumann, R.; Lesinski-Schiedat, A.; Goldring, J.E.; Gnadeberg, D.; Rittmann, K.L.; Battmer, R.D.; Karstens, J.; Lenarz, T. 1999: The influence of ionizing radiation on the CLARION 1.2 cochlear implant during radiation therapy American Journal of Otology 20(1): 50-52
Yan, C.; Wang, Z-He. 2008: Research advances in prevention of radiation induced xerostomia by intensity-modulated radiation therapy Shanghai Kou Qiang Yi Xue 17(5): 540-544
Jaffe, D.; Bowden, G.T. 1987: Ionizing radiation as an initiator: effects of proliferation and promotion time on tumor incidence in mice Cancer Research 47(24 Part 1): 6692-6696
Masaki, N.; Ikeda, H.; Hayabuchi, N.; Niibe, H.; Kaneta, H.; Morita, K.; Horiuchi, J.; Watanabe, S. 1988: Results of radiation therapy of stage I-II non-Hodgkin's lymphoma localized in the head and neck--a report of the Japanese Lymphoma Radiation Therapy Study Group Gan no Rinsho. Japan Journal of Cancer Clinics 34(5): 581-588
Bernardi, G. 2001: Endoluminal beta-radiation therapy for the prevention of coronary restenosis after balloon angioplasty. Localized intracoronary gamma-radiation therapy to inhibit the recurrence of restenosis after stenting Italian Heart Journal. Supplement: Official Journal of the Italian Federation of Cardiology 2(5): 559-562
Masaki, N.; Ikeda, H.; Kaneta, K.; Morita, K.; Niibe, H.; Watanabe, S.; Hayabuchi, N.; Horiuchi, J. 1988: Results of radiation therapy of stage II non-Hodgkin's lymphoma of the Waldeyer's ring: a report of the Japanese Lymphoma Radiation Therapy Study Group Gan no Rinsho. Japan Journal of Cancer Clinics 34(5): 612-618
Alberti, C. 2011: Organ-confined prostate carcinoma radiation brachytherapy compared with external either photon- or hadron-beam radiation therapy. just a short up-to-date European Review for Medical and Pharmacological Sciences 15(7): 769-774
Gajewski, A.K.; Slowikowska, M.G.; Chomiczewski, K.; Szram, S. 1975: Delayed results of irradiation of newborn mice with gamma rays. IV. Effect of sex and radiation dosage on the extent of radiation-induced injury Roczniki Panstwowego Zakladu Higieny 26(2): 263-277
Ferrara, P.; Cimino, A.; Tortorici, M. 1987: Role of radiation therapy in glomus tumor American Journal of Otology 8(5): 390-395
Loeb, R.A. 1971: Radiation therapy of cancer. Tumor sensitivity and resistance. 2 Pennsylvania Medicine 74(12): 60
2016: (P008) Prospective Assessment of Simulated Prone Whole-Breast Radiation Therapy vs Supine Whole-Breast Radiation Therapy With Respiratory Gating: Significant Lung Dose Reduction With Prone Positioning Oncology 30 Suppl
Kaneta, K.; Kawabata, K.; Hayabuchi, N.; Masaki, N.; Morita, K.; Horiuchi, J.; Niibe, H.; Watanabe, S. 1988: Results of radiation therapy of stage i and Ii nodal non-Hodgkin's lymphoma originated in the cervical lymph nodes--a study of the Japan Lymphoma Radiation Therapy Study Group Gan no Rinsho. Japan Journal of Cancer Clinics 34(5): 644-650
Leichman, L.; Steiger, Z.; Seydel, H.G.; Vaitkevicius, V.K. 1984: Combined preoperative chemotherapy and radiation therapy for cancer of the esophagus: the Wayne State University, Southwest Oncology group and Radiation Therapy Oncology Group experience Seminars in Oncology 11(2): 178-185