Antagonism of acute copper (II) -induced renal lesions by sodium 2,3-dimercaptopropanesulfonate
Mitchell, W.M.; Basinger, M.A.; Jones, M.M.
Johns Hopkins Medical Journal 151(6): 283-285
1982
ISSN/ISBN: 0021-7263 PMID: 7176288 Document Number: 183589
Acute copper(II) sulfate poisoning in the mouse induces renal tubular degeneration and necrosis. Timely administration of sodium 2,3-dimercaptopropane-sulfonate (DMPS) effectively prevented the development of the morphological renal sequelae of copper intoxication. During the time course of this study (5 days), no copper-induced hepatic lesions were observed. DMPS and its preformed copper complex possess low inherent toxicity with no hepatorenal lesions occurring over a 5-day period. These findings suggest that DMPS may be an effective antidote in acute and chronic copper poisoning in humans.