Tuberculosis in patients with systemic lupus erythematosus

Balakrishnan, C.; Mangat, G.; Mittal, G.; Joshi, V.R.

Journal of the Association of Physicians of India 46(8): 682-683

1998


ISSN/ISBN: 0004-5772
PMID: 11229272
Document Number: 18275
In a retrospective analysis of 146 systemic lupus erythematosus (SLE) patients seen over a 5 year period, 17 patients of tuberculosis (TB) were identified yielding a prevalence rate of 11.6%. The median duration of SLE was 12 months (range 2-96 months) and 12/17 patients had disease activity score of more than five. The median duration of steroid treatment was 12 months (range 0-96 months) and the median cummulative dose of steroid was 7.75 gms (range 0-22.1 gms). Pulmonary TB (miliary-5, nonmiliary infiltrates-7 and pleural effusion-2) was the commonest type and there was an average diagnostic delay of approximately 1 month. While, majority of the patients responded adequately to treatment, 1 patient had a relapse and 1 expired due to a combination of active lupus and disseminated TB. Only 1 patient had received prophylactic isoniazid.

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Tuberculosis in patients with systemic lupus erythematosus