Various characteristics of catecholamine metabolism in thyrotoxicosis
Rom-Bugoslavskaia, E.S.; Kharag, G.I.
Problemy Endokrinologii 27(5): 6-12
1981
ISSN/ISBN: 0375-9660 PMID: 7291163 Document Number: 181126
Catecholamine metabolism was studied and compared with thyrotoxicosis in 205 patients, depending on the age, illness severity and therapy type. Analysis of the data obtained allowed one to observe some peculiarities of catecholamine metabolism in thyroid hyperfunction: i. e. biosynthesis inhibition and catecholamine metabolism intensification, shunting of these monoamine metabolic changes from oxidative deamination to O-methylation with simultaneous H- and O-methylation growing. The role of thyroid hormones in catecholamine biosynthesis and metabolic deactivation was proved. Such an effect on thyroid hormones is estimated as a reaction, promoting inhibition of the sympathycoadrenal system functional activity.