Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency
Ganer, A.; Knobel, B.; Fryd, C.H.; Rachmilewitz, E.A.
Israel Journal of Medical Sciences 17(8): 703-704
1981
ISSN/ISBN: 0021-2180 PMID: 6765904 Document Number: 180747
Methemoglobinemia and hemolysis are well-known side effects after using high doses of dapsone (4,4'-diaminodiphenylsulfone). Their occurrence after low doses of the drug, and subsequent investigation, revealed the presence of hemoglobin Hasharon, and low content of NADH-dependent methemoglobin reductase in five members of an East European ashkenazic Jewish family.