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Carrier mechanism and specificity accounting for the increase in intracellular melphalan by the basic amino acids

Vistica, D.T.; Schuette, B.P.

Molecular Pharmacology 19(1): 92-96

1981

ISSN/ISBN: 0026-895X
PMID: 7207465
Document Number: 180660
The basic amino acids arginine and its lower homologue, .alpha.-amino-.gamma.-guanidinobutyric acid, increased [mouse leukemia L1210] intracellular melphalan levels only in the presence of leucine and Na+. This increase occurred solely through the monovalent cation-dependent, high-affinity, leucine-preferring transport system, 1 of the 2 amino acid transport systems responsible for melphalan uptake. Acceleration of melphalan exodus by leucine is antagonized by .alpha.-amino-.gamma.-guanidinobutyric acid, resulting in increased cellular retention of melphalan.

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