Grumose alteration of the cerebellar dentate nucleus in two cases of progressive supranuclear palsy
Martin, J.J.; Dehaene, I.; Shiraki, H.
Acta Neurologica Belgica 81(3): 137-143
1981
ISSN/ISBN: 0300-9009 PMID: 7304125 Document Number: 179727
The purpose of this paper is to illustrate an interesting lesion of the cerebellar dendate nucleus: the grumose alteration which is demonstrated by silver impregnation techniques in two cases of progressive supranuclear palsy. The grumose alteration is nearly exclusively found in the parvocellular part of the dentate nucleus; it is characterized by a clustering of granules and ring-shaped bodies against neuronal perikarya and dentrites; it corresponds very likely to reactive presynaptic endings of Purkinje cells' axons. Similar lesions can be discovered in various neurodegenerative disorders. The morphologic features of the grumose alteration are reviewed.