CSF monoamine metabolites in patients with progressive supranuclear palsy
Yamamoto, M.; Ujike, H.; Kohira, I.; Ogasawara, N.; Ogawa, N.
Rinsho Shinkeigaku 32(3): 272-275
1992
ISSN/ISBN: 0009-918X PMID: 1378366 Document Number: 391224
Neurochemical abnormalities in the patients with progressive supranuclear palsy (PSP) are not well understood. We investigated CSF levels of the monoamine metabolites HVA, 5HIAA and MHPG in 5 patients with PSP in order to investigate, especially dopaminergic, serotonergic and noradrenergic metabolism. Results were as follows (value; mena +/- S.D.). [table: see text] The levels of HVA were significantly lower than those in controls. These findings suggest that there is a hypofunction of dopaminergic neurons in PSP patients.