Dupilumab Treatment for Prurigo Nodularis and Pruritis
Tanis, R.; Ferenczi, K.; Payette, M.
Journal of Drugs in Dermatology Jdd 18(9): 940-942
2019
ISSN/ISBN: 1545-9616 PMID: 31524352 Document Number: 17942
Prurigo nodularis (PN) is a disease in which chronic scratching and picking of the skin due to intense pruritis results in papulonodules, notably in areas that are accessible to the patient. The pathophysiology is hypothesized to be mediated by a Th2 helper cell response, similar to that seen in atopic dermatitis, therefore, treatment of PN with dupilumab would be expected to elicit a therapeutic response. We demonstrated that treatment of PN with dupilumab significantly decreased pruritis and the size and number of new lesions after 2 months of treatment.
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