The effect of oxidant injury on the lymphocyte membrane and functions
Kraut, E.H.; Sagone, A.L.
Journal of Laboratory and Clinical Medicine 98(5): 697-703
1981
ISSN/ISBN: 0022-2143 PMID: 6457885 Document Number: 179355
The effect of oxidant stress on the lymphocyte membrane and lymphocyte functions of humans was studied. Lymphocyte cultures were incubated with xanthine oxidase and xanthine, an enzyme system known to generate several highly reactive O2 compounds. These lymphocytes were viable after exposure to an in vitro oxidant stress. There was a marked reduction in their ability to bind SRBC , was not impaired after oxidant injury. After in vitro oxidant injury, lymphocytes may have alterations in the cell membrane and impaired function.