The effect of benzopyrones on pancreatic secretion in anaesthetized dogs with short-term ischaemia
Nozicková, M.; Bartos, V.; Hachowá, L.
Materia Medica Polona. Polish Journal of Medicine and Pharmacy 13(1): 23-25
1981
ISSN/ISBN: 0025-5246 PMID: 7321583 Document Number: 178580
Pancreatic secretion stimulated by continual infusion of secretin and pancreozymin was studied in 14 anesthetized dogs before and after short-term ischemia of the pancreas. Seven dogs were given a combination of coumarin and rutin sulfate (Venalot) before the induction of ischemia and during revascularization. The drug did not affect pancreatic secretion during the pre-ischemic phase. During the post-ischemia phase, the volume of secretion and output of bicarbonate and amylase were significantly higher in the Venalot-treated dogs than in the controls. Both groups showed a marked disturbance of exocrine pancreatic function. This effect of Venalot is attributed to its antiedematous action.