Interference of mycotoxins with prenatal development of the mouse. II. Ochratoxin A induced teratogenic effects in relation to the dose and stage of gestation
Arora, R.G.; Frölén, H.
Acta Veterinaria Scandinavica 22(3-4): 535-552
1981
ISSN/ISBN: 0044-605X PMID: 7344537 Document Number: 178567
Ochratoxin A was dissolved in corn oil and administered by stomach tube to pregnant CBA mice in varying dosages. On gestation day 8 or 9 the dams were treated with a dose of either 1, 2 or 4 mg/kg body weight and on one of various other days (2, 4, 6-7, 10-14, 16) or two days prior to conception they were supplied with a dose of 4 mg/kg. The highest amount of the toxin given at 7, 8 or 9 days decreased prenatal survival and, on the 9th day, diminished fetal growth. A marked impairment in fetal growth also resulted from treatment before conception. Overt craniofacial anomalies were produced only by exposure at 8 or 9 days, and their incidence, multiplicity and severity increased with increasing dosage, the peak effect being on day 9. A study of the anatomical features of the craniofacial skeleton disclosed the failure of closure of neurocranium and an abnormal configuration, position and size of the bones of the base and lateral walls of the skull.