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Role of peroxidation in destruction of membrane lipids under conditions of liver ischemia

Dudnik, L.B.; Bilenko, M.V.; Alesenko, A.V.; Mogilevskaia, M.P.; Burlakova, E.B.

Voprosy Meditsinskoi Khimii 27(3): 380-383

1981

ISSN/ISBN: 0042-8809
PMID: 7281581
Document Number: 177774
Alterations in phospholipid and fatty acid composition were studied in homogenates, mitochondrial, microsomal and nuclear fractions during intensification of lipid peroxidation under conditions of liver tissue ischemia. Increase in content of lipid hydroperoxides and decrease in content of arachidonic acid were observed in lipids of all the membranes studied. Content of individual phospholipids altered depending on their susceptibility to peroxidation. In ischemia content of total lipids and phospholipids was decreased. The data obtained suggest the important role of peroxidation in impairment of membrane lipids under conditions of ischemia.

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