Structuro-metabolic integration of gastric endocrine cells in the presence of a disruption in hormone balance
Fedchenko, S.N.
Arkhiv Anatomii Gistologii i Embriologii 80(3): 68-77
1981
ISSN/ISBN: 0004-1947 PMID: 6114727 Document Number: 176974
In experimentally hyperthyroid rats an increased amount of gastrin-producing (G) and histamine-producing (ECl) cells was noted by means of immunofluorescent biochemical methods and electron microscopically. Increased amount of the ECl cells was combined with a rise in histamine contents in the gastric mucosa. Hydrocortisone injections resulted in degranulation of the G- and ECl-cells. After hydrocortisone injection, the amount of histamine decreased more than two-fold. It was demonstrated that not only parietal glandulocytes, but also the gastric endocrine cells participated in disorders of a complex acid-producing mechanism.