Single dose cefazolin is safe and effective for pre-operative prophylaxis in orthopaedic oncology

Ziranu, A.; Lillo, M.; Fantoni, M.; Maffulli, N.; Maccauro, G.

Journal of Biological Regulators and Homeostatic Agents 32(6 Part 1): 45-49

2018


ISSN/ISBN: 0393-974X
PMID: 30644281
Document Number: 17685
Surgical site infections (SSI) are a common potentially preventable complication after surgical procedures. A standardized antibiotic prophylaxis in elective orthopaedic surgery plays a major role in lowering SSI. At present, there is little published evidence regarding standardized antibiotic prophylaxis in orthopaedic oncological surgery. We introduced a prophylactic antibiotic protocol for orthopaedic oncological surgery in our hospital. The proposed protocol consists in "one-shot" intravenous administration of Cefazolin 2g, 30 min before surgery. In our setting, this preoperative antibiotic prophylaxis regimen was associated with a markedly lower rate of SSI's. There is no current evidence in favour of greater effectiveness of prophylaxis beyond 24/48 h after surgery compared to our pre-surgical "one-shot" administration; by contrast, prolonged post-surgical prophylaxis is likely to undermine the patient's bacterial flora and select resistant pathogens. These results are preliminary and should be used to start planning a standardised prophylactic protocol to prevent SSI's after orthopaedic oncological surgery.

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Single dose cefazolin is safe and effective for pre-operative prophylaxis in orthopaedic oncology