Semimalignant" osteoma cutis
Worret, W.I.; Klehr, N.W.; Bretz, S.; Strauss, P.
Der Hautarzt; Zeitschrift für Dermatologie Venerologie und verwandte Gebiete 32(8): 413-416
1981
ISSN/ISBN: 0017-8470 PMID: 7275572 Document Number: 176775
A tumor is reported which originated rom an osteoma cutis and expanded into the surrounding tissue by infiltration and destruction. Histologically, there were no signs of malignancy. In cell culture there grew populations of bone-like tissue with highly active metabolism and negative contact inhibition. Therapeutic trials with diphosphonate are discussed.