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Successful Treatment of Pemphigus Vulgaris with Ofatumumab

Rapp, M.; Pentland, A.; Richardson, C.

Journal of Drugs in Dermatology Jdd 17(12): 1338-1339

2018

ISSN/ISBN: 1545-9616
PMID: 30586270
Document Number: 17672
Rituximab is a chimeric anti-CD20 monoclonal antibody that is very effective in treating patients with pemphigus vulgaris. Though infrequent, the development of human anti-chimeric antibodies in patients receiving rituximab results in loss of efficacy. Ofatumumab is a second-generation fully-human anti-CD20 monoclonal antibody currently used to treat chronic lymphocytic leukemia. We report a case of a patient with pemphigus vulgaris successfully treated with ofatumumab after developing human anti-chimeric antibodies to rituximab.

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Successful Treatment of Pemphigus Vulgaris with Ofatumumab

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