Effect of Leucogenenol on recovery from immunosuppressin by anti-lymphocyte globulins
Rice, F.A.; Koo, M.J.
Journal of Immunology 127(4): 1601-1603
1981
ISSN/ISBN: 0022-1767 PMID: 7024411 Document Number: 176366
Daily treatment of rats with the thymothyroid hormone leucogenenol after their immunosuppression with antilymphocyte globulins causes the rats to regain their immunocompetency after 7 days of treatment, in contrast to well over 1 mo., which is required for untreated controls. Immunocompetency was measured by the ability of the rat to respond to the injection of sheep erythrocytes with the formation of normal concentrations of antibody-forming cells in their lymphoid tissues and normal titers of hemolysins in their serum. Leucogenenol apparently increases the rate of development of T cells and B cells from committed precursors.