Comparison of the antimitotic properties of cyclophosphamide and its biotransformation products on meristema plant cells and animal cells in in vitro culture
Deysson, G.; Adolphe, M.; Semont, H.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 175(2): 182-186
1981
ISSN/ISBN: 0037-9026 PMID: 6454464 Document Number: 176047
N-mustard diamide phosphoric and above all 4-hydroperoxycyclophosphamide are clearly more cytotoxic than same kind, which is in accordance with the fact that these compounds are the active metabolites of cyclophosphamide. On the contrary, 4-ketocyclophosphamide and carboxyphosphamide, secondary metabolites inapt to be activated, are not more cytotoxic than cyclophosphamide. No tolerance does occur with these metabolites, contrary to cyclophosphamide itself.