Maternal treatment with indomethacin and severe neonatal pulmonary hypertension
Dalens, B.; Dechelotte, P.; Gaulme, J.; Raynaud, E.J.
Archives Francaises de Pediatrie 38(4): 261-265
1981
ISSN/ISBN: 0003-9764 PMID: 7294953 Document Number: 175426
The authors report five cases of premature newborns whose mothers had been treated with indomethacin. In all patients, clinical and biological symptoms were those of pulmonary hypertension with persistence of the fetal circulation. In two cases, autopsy showed an important reduction of the lumen of pulmonary arterioles due to a thickening of the tunica media. The role of indomethacin in such respiratory syndrome is very likely. Therefore, indications for that treatment in pregnant women should be reduced.
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