Primary myelofibrosis terminating in myeloblastic transformation within a short time
Yonemitsu, H.; Shigeta, H.; Kanazawa, S.; Yamaguchi, K.; Okuda, K.
Nihon Ketsueki Gakkai Zasshi Journal of Japan Haematological Society 44(1): 86-89
1981
ISSN/ISBN: 0001-5806 PMID: 6947678 Document Number: 175398
A 43-yr-old man with primary myelofibrosis terminating in myeloblastic transformation in a rapidly fatal course is described. He had no splenomegaly on admission. Hematologic studies showed leukoerythroblastic anemia with marked eosinophilia. A biopsy of the bone marrow revealed a picture of myelofibrosis. Blastic transformation occurred 7 mo. after the diagnosis. Necropsy showed myeloblastic infiltration in the spleen and liver. The disease is considered to be an atypical form of primary myelofibrosis.