Paediatrics primary myelofibrosis and acute stroke: A rare presentation
Mazher, W.; Rizvi, A.Hasan.; Adam, A.Majeed.; Ali Mallick, M.Saad.; Godil, A.
Jpma. Journal of the Pakistan Medical Association 67(4): 634-636
2017
ISSN/ISBN: 0030-9982 PMID: 28420931 Document Number: 692966
Idiopathic Myelofibrosis is a rare myeloproliferative disorder. In children, it becomes even rarer. Herein, we report a case of idiopathic myelofibrosis of a 6-year old male patient who presented with complaints of pallor, petechiae and bleeding from gums. Bone marrow aspirate showed afragmented haemodiluted smears with erythroid and myeloid precursors scattered throughout. Trephine biopsy showed increased background fibrotic activity along with clusters of histiocytes. A diagnosis of paediatric primary myelofibrosis was made on biopsy. The patient also developed a stroke that resulted in left-sided hemiparesis. An MRI suggested an intraparenchymal haemorrhage along with meningeal extramedullary haematopoiesis.