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Interaction of monomeric components of nucleic acids with histone and polylysine in the presence of formaldehyde

Volkov, V.S.; Semin, I.A.; Poverennyĭ, A.M.

Biokhimiia 46(10): 1832-1839

1981

ISSN/ISBN: 0320-9725
PMID: 7306603
Document Number: 175360
The ability of various nucleosides and nucleotides to bind to histone and polylysine upon formaldehyde treatment was investigated. In protein or polypeptide preparations the guanine derivatives are present in much greater amounts than other nucleic base derivatives. No synthesis of stable products was observed. The formation of the DNA - histone complex upon nuclear histone treatment with formaldehyde probably depends on the formaldehyde-induced reaction between the histone and guanine bases of DNA.

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