Immunoglobulin concentrations in the duodenal fluids of infants and children. II. The effect of pancreozymin and secretin
Lebenthal, E.; Clark, B.
American Journal of Gastroenterology 75(6): 436-439
1981
ISSN/ISBN: 0002-9270 PMID: 7270539 Document Number: 174565
Whether pancreozymin and secretin affect the levels of Ig in duodenal fluid of children was studied. The subjects consisted of 45 infants and children without gastrointestinal disease. IgA concentrations in duodenal fluid were significantly increased (P < 0.02) after secretin administration (2 U/kg) as compared to resting fluid levels (18.3 .+-. 0.8 vs. 12.9 .+-. 1.1 mg/g protein). Secretin also produced a significant increase (P < 0.0002) in IgM duodenal fluid levels (25.5 .+-. 3.6 vs. 13.8 .+-. 1.4 mg/g protein). Duodenal fluid IgG concentrations were not significantly changed in response to secretin (30.7 .+-. 2.3 vs. 29.1 .+-. 1.2 mg/g protein) or to pancreozymin (29.0 .+-. 0.8 mg/g protein). Pancreozymin administration (2 U/kg) produced a significant decrease (P < 0.01) in IgA concentration (11.2 .+-. 0.8 mg/g protein) and a significant increase (P < 0.0002) in the IgM levels of human duodenal fluid (20.8 .+-. 1.8 mg/g protein).