Interrelationship of the tranquilizers diazepam and lonetil with dopamine mediation in the central nervous system
Ovcharov, R.; Danchev, N.
Eksperimentalna Meditsina i Morfologiia 20(2): 88-96
1981
ISSN/ISBN: 0367-0643 PMID: 7250025 Document Number: 174440
The tranquilizers Diazepam and Lonetyl were examined on rats for their influence on the higher nervous system, using the method of "double escape". Pharmacologic analysis of their action on dopaminergic structures in the central nervous system was performed as well. In this analysis they used dopamine agonist Apomorphine and dopamine antagonist Haloperidol. The authors established that diazepam is small doses did not inhibit dopaminergic system and its activation affected favourably its action, improving conditioned reflex activity. Inhibition of dopaminergic activity by Haloperidol reduced the effect of Diazepam. Lonetil, in contrast to diazepam, inhibited dopaminergic mediation and its sedative effect was increased considerably by Haloperidol.