Significance of uric acid concentration in the serum for the early recognition of the risk of EPH gestosis
Riedel, H.
Fortschritte der Medizin 99(37): 1505-1510
1981
ISSN/ISBN: 0015-8178 PMID: 7297989 Document Number: 174242
102 patients with EPH-gestosis in different stages of severity and 29 patients with normal pregnancy were examined regularly in a longitudinal study. 54 clinical and laboratory parameters were continuously measured. The concentration of uric acid in serum has proven to be the most important parameter in the early detection of the risk of gestosis. This serum concentration correlates with blood pressure and in individual cases shown to be of additional predictive value. Significant differences, compared to normal pregnancy, exist already in the 17th to the 24th week. Until now these differences had been described for a much later period. Other laboratory parameters have not been useful at this early stage in the detection of likely development of EPH-gestosis. Hyperuricemia is primarily due to the isolated reduction of uric acid clearance by normal glomerular filtration rate. Thus it is assumed that hyperuricemia is an indication of renal cortical blood flow dysfunction which parallels the decreased perfusion of the placenta.