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Mast Cell Burden in a Patient with Cutaneous Disease

Awosika, O.; Eleryan, M.; Rengifo-Pardo, M.; Ehrlich, A.

Journal of Drugs in Dermatology Jdd 16(12): 1285-1287

2017

ISSN/ISBN: 1545-9616
PMID: 29240865
Document Number: 17406
Mastocytosis is a disease characterized by the abnormal clonal proliferation of mast cells in skin and/or extracutaneous organs, often relating to activating mutations of c-KIT. Histopathology special stains, such as Giemsa, Leder, and Toluidine blue, are key for the diagnosis of cutaneous mastocytosis (CM). In adults, skin lesions can be associated with systemic disease. Tryptase is a diagnostic marker in mastocytosis and thought to reflect the burden of mast cell disease. In this report, we present a case of cutaneous mast cell disease with associated findings of elevated serum tryptase and mast cell infiltration of the bone marrow consistent with indolent systemic mastocytosis.

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Mast Cell Burden in a Patient with Cutaneous Disease

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