Complete remission following recombinant interferon alpha-2a in a patient with diffuse large B cell cutaneous lymphoma
Tourani, J.M.; Leaute, J.B.; Lessana-Leibowitch, M.; Andrieu, J.M.
Nouvelle Revue Francaise d'Hematologie 31(4): 315-316
1989
ISSN/ISBN: 0029-4810 PMID: 2691984 Document Number: 340620
Recombinant interferon alpha (r IFN alpha) has shown significant antitumor activity in patients with follicular small cleaved cell (low-grade non-Hodgkin's lymphomas) and cutaneous T-cell lymphomas. However, IFN alpha seems to be less effective in patients with intermediate or high-grade lymphomas. This case report describes a patient with an initial diagnosis of low grade B-cell lymphoma with histologic conversion to diffuse large B-cell (B1+, Kappa+) cutaneous lymphoma. This tumor proved refractory to chemotherapy but a complete and durable remission was induced with R IFN alpha 2a treatment.