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Further studies on the mechanism of action of methyldopa on the vas deferens of the guinea-pig

Tayo, F.M.

Archives Internationales de Pharmacodynamie et de Therapie 254(1): 38-42

1981

ISSN/ISBN: 0003-9780
PMID: 7337493
Document Number: 173954
Methyldopa (400 micrograms/ml) abolished neurally evoked contractions of the guinea-pig vas deferens after 1.5 hr incubation. The tissue became supersensitive to noradrenaline and acetylcholine but was now insensitive to potassium chloride. On the other hand, tissues treated with 6-hydroxydopamine (6-OHDA) were supersensitive to noradrenaline but not to acetylcholine. The results suggest that cholinergic mechanisms may also be affected by methyldopa.

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