Lactate Non-Clearance versus Lactate Clearance: a Comparison of Hospital Mortality in High-Risk Surgical Patients
Thawitsri, T.; Thongdee, S.; Chokengarmwong, N.; Kongwibulwut, M.; Kumwilaisak, K.; Poonyathawon, S.; Chatkaew, P.; Charuluxananan, S.
Journal of the Medical Association of Thailand 99(Suppl 6): S201-S208
2016
ISSN/ISBN: 0125-2208 PMID: 29906379 Document Number: 17391
The optimal endpoints of resuscitation in high-risk surgical patients remain controversial. Specifically, it is difficult to establish the effective predictive markers as the endpoints of resuscitation in this patient group. Therefore, the study was conducted to assess the predictive value of early lactate non-clearance condition on hospital mortality in high-risk surgical patients. The study is a prospective analytic study. The data were collected in one university-based surgical intensive care unit (SICU) over a 5-month period. All consecutive adult high-risk surgical patients admitted to SICU in postoperative period were recruited to the study. Blood lactate levels were measured on SICU admission (0-hour), 12 hours later, and then calculated for 12-hour blood lactate clearance. The authors categorized the patients into two groups: lactate clearance (LC) and lactate non-clearance (LNC). After that, the patients were monitored until hospital discharge or inhospital death. There were 122 high-risk surgical patients recruited to the study. As concerns the factors of interest, higher In high-risk surgical patients, 12-hour LNC cannot demonstrate the prognostic value for hospital morbidity