Antithrombin activity during estroprogestin therapy
Ferrari, S.; Brazzoli, C.; Pezzini, M.B.; Zanoio, L.; Benini, F.
Minerva Ginecologica 33(5): 429-432
1981
ISSN/ISBN: 0026-4784 PMID: 7254664 Document Number: 173783
50 women on estroprogestational contraceptive treatment, and 48 healthy controls were observed to examine antithrombin activity, heparin-thrombin activity, and fibrinogen. Antithrombin activity and heparin-thrombin activity decreased significantly in women under OC (oral contraception) treatment, while fibrinogen did not increase significantly. No correlation was found between duration of therapy and antithrombin activity decrease. It is possible that there are 2 groups of women, one with normal antithrombin activity, and one with reduced activity; this last group of patients could be more at risk of hypercoagulation accidents, and should be checked more often.