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Further studies on the effect of fibrinopeptides a and B on the central nervous system

Bernacka, I.; Buczko, W.; Wiśniewski, K.

Polish Journal of Pharmacology and Pharmacy 33(4): 407-414

1981

ISSN/ISBN: 0301-0244
PMID: 7329866
Document Number: 173598
Fibrinopeptides A and B (FAB) given intraperitoneally increased general activity of rats without affecting motor coordination. FAB depressed thiopental-induced sleeping time, prolonged the latency of pentetrazol convulsions, shortened the tonic phase of electrogenic convulsions. The peptides depressed the dopamine level in investigated brain areas of rats and increased the level of homovanillic acid. FAB accelerated the disappearance of dopamine after alpha-methyl-p-tyrosine injection. The data indicate tha FAB stimulate the central nervous system and this seems to be related to their interaction with the central dopaminergic system.

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